One of the most popular agglomeration machines in the pharmaceutical sector is the fertilizer granulation equipment. Wet massing of the powder mixture with a crushing fluid, wet estimating, and drying are the main components of the wet granulation measure.
Pharmaceutical firms have access to a variety of granulation methods. Given how crucial granulation is to the creation of oral dosage forms, wet granulation machines play a significant role.
This article, however, will walk you through every step of the process, from learning about the types of wet granulation to comparing several related techniques and outlining all the advantages and disadvantages of the machine.
Wet Granulation
The method of wet granulation involves adding a fluid, known as granulating fluid, to powdered drugs, which causes granules to form. The granulating liquid is useful in conjunction with the powdered material’s particles during the wet granulation process.
A liquid with a carrier substance—which might be a solvent—in it is called a granulating fluid. The carrier substance’s ability to evaporate is a crucial prerequisite. The demand for carrier volatility stems from the ease of removal of the granulating fluid.
Additionally, the granulating fluid needs to be non-toxic to protect the drug that is being prepared.
Benefits of the Wet Granulation Method
Wet granulation is a crucial procedure that offers several benefits across a variety of sectors, particularly the pharmaceutical sector.
The following is a list of some benefits of wet fertilizer granulation machinery.
Facilitates the Easy Creation of Homogenous Mixtures
Wet granulation makes it very easy to create a uniform blend of your powdered items. This can be attributed to two factors. First, the granulating fluid is added to the powdered product; second, the wet granulation machine’s unique design.
A suitable medium for combining powders is provided by the granulating fluid, and the wet granulation machine’s rotatory impeller aids in properly mixing the particles. The wet granulation machine makes it relatively simple to achieve a uniform mixture in this way.
Improves the Particles’ Flowability
As previously stated, granulating fluid is added to the powdered material during the wet granulation process, increasing its moisture content. Lowering the friction, improves the particle flow. The lubrication that the granulating fluid provides lowers the friction.
The entire process of improved flow and decreased friction facilitates the easy formation of the powdered material’s granules.
Effectiveness
The wet granulation procedure is far more effective than the dry granulation method. Because of this, it is a better technique than dry granulation.
Producing Dense Granules Is Easy
A granulating fluid is a part of the powdered material during the wet granulation process. This inclusion is essential and contributes significantly to the ease of producing thick granules.
Environmental Aspects
When discussing the effectiveness of any procedure, environmental elements are in consideration. These days, governments everywhere place a strong emphasis on preserving the environment by lowering pollution; hence, procedures that result in less pollution are in favor.
An essential part of preventing air pollution is the wet granulation process. It prevents air pollution by preventing dust particles from simply escaping into the atmosphere.
